We've already seen that playing on the Sunday after a EL game on a Thursday is challenging. We took a lot of positives from the Wolfsburg game into the Palace game but were still shocking. We have to accept that playing the two games in such close proximity is going to mean changes to the line up. Even sending a full strength side to Russia is no guarantee of a win, but it would probably mean a weaker side playing against Man Utd.
As I said before, a loss on Thursday after fielding a weakened team won't harm our chances of progressing in the EL (which I really want us to do), but another heavy league defeat could do real harm to the teams confidence.